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In this article, we will discuss hemicrania continua, which is a type of continuous headache. Around 1.7 to 4% of the global adult population experience a headache for 15 days or more, every month.

Different types of headaches can occur in response to internal or external factors. In order to get the right treatment, you need to understand the type of headache you are experiencing.

We will focus on what it is, symptoms and treatments, and how to differentiate it from other chronic headaches.

What Is Hemicrania Continua?

Another Type Of Headache

It is estimated that around 1% of all headache cases are hemicrania continua. According to the international classification of headache disorders, headaches can be divided into primary headaches and symptomatic headaches.

A primary headache is one that is not caused by another health condition while a symptomatic headache is a symptom of another health condition. This type of headache is classified as a rare primary headache disorder.

The term hemicrania continua was first coined in the year 1984. It is derived from Latin and describes the key features of this condition, with hemicrania meaning one side of the head and continua meaning continuous.

As its name suggests, hemicrania continua is a continuous headache that is unilateral, meaning that it occurs only on one side of the head. This condition can cause moderate to severe pain.


A study has shown that the condition can be accompanied by fluctuating headache exacerbation (worsening pain attacks) which can last for a few minutes or up to a few days. You may experience these attacks more than 20 times every day or only once in 4 months.

About 50% of patients report one attack every day. These attacks can cause moderate to very severe pain. This pain is throbbing or stabbing in character.

If you have had a one-sided continued headache for more than three months, you may be suffering from hemicrania continua.

Gender, Age, and Ethnic Prevalence

Women are more likely to suffer from one than men. This condition is also more prevalent in adults in their thirties and forties, although symptoms may manifest themselves in anyone aged between 5 to 67 years.

People of all racial and ethnic groups may be affected globally. However, this type of condition is still being underreported and underdiagnosed.

Causes and Triggers

At present, it is not known what causes this condition but it has been suggested that the overuse of certain drugs such as analgesics (pain killers) is a likely cause. There is also some indication that alcohol use or physical exertion may worsen the pain.

This type of head pain can be extremely disabling, and it is thus crucial to diagnose this condition early on to help in achieving a pain-free state.

What Are The Symptoms of Hemicrania Continua?

Check this list for some of the common symptoms:

  • a constant unilateral head pain, lasting for a period of over 3 months, with exacerbations of moderate or higher intensity
  • eye tearing on the same side as the headache
  • nasal congestion and/or runny nose
  • sweating on the face or forehead
  • ptosis – drooping eyelid on the same side as the headache
  • miosis – contracture of the iris
  • eye redness on the same side as the headache

It can also cause similar symptoms to migraines such as:

  • nausea or vomiting
  • sensitivity to light or noise
  • throbbing pain

Certain activities and lifestyle habits tend to worsen the symptoms, such as:

  • physical exertion
  • fatigue
  • changes in sleeping patterns
  • bright lights
  • stress
  • alcohol

Some patients have also reported that they experience symptoms of the condition when they rotate or flex their neck or if they feel pressure on their neck.

Pain Location

Although the pain typically occurs on only one side of the head, with a slight preference to occur on the right side, the pain may shift sides in some rare cases. About 20% of patients may also be pain-free for a duration of one day to several days, although in general, this headache is associated with continuous head pain.

If this condition is properly diagnosed, it can be treated effectively.

How To Treat Continuous Headache

What Are The Treatment Options?

Indomethacin Headache Treatment

The most effective medication in treating hemicrania continua is indomethacin which is a non-steroidal anti-inflammatory drug. In fact, one of the ways your doctor can know if you suffer from this condition is if your pain goes away after you have taken indomethacin for headaches.

However, in some cases, you may be required to do more tests such as an MRI scan so that your doctor can better understand your symptoms even if you show a complete response to this medication.


You would typically take a low dosage of 25mg. three times per day with your meals and your doctor will adjust your dosage, depending on how you are responding to the treatment. People suffering from this condition typically respond to this medication within 24 hours, but some may take up to one week to respond.

Your doctor will usually increase your dosage if you do not respond to treatment within 48 to 72 hours after you have taken the medication. In such cases, the maximum dosage that your doctor can prescribe to you is 300 mg per day

Possible Side Effects of Indomethacin

Like all other medications, indomethacin also has certain side effects which include the following:

  • abdominal pain
  • heartburn
  • nausea and vomiting
  • gastrointestinal hemorrhage
  • hypertension
  • kidney and liver failure

Indomethacin treatment is usually long term or can even last a lifetime. Thus, it is essential that you keep your dosage at the lowest level possible to prevent adverse effects. It is also possible to gradually reduce your dosage over time without your head pain occurring again. This successful tapering off has been reported in many patients.

Alternative Medications for Hemicrania Continua

If you are not able to tolerate the side effects of indomethacin, you can use other medications but they are not as effective. Some of these drugs include melatonin, celecoxib, gabapentin, or topiramate.

Melatonin is a natural hormone whose structure is similar to that of indomethacin. It can be used in conjunction. You can then use a lower dosage of indomethacin to reduce its adverse effects.

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Celecoxib is a nonsteroidal anti-inflammatory drug that has proved to be another good alternative in patients who report adverse reactions to indomethacin.

A medical study has shown that gabapentin is a good alternative medication, with 7 out of 9 patients reporting at least a 50% pain reduction when administered with gabapentin. 4 patients reported being totally pain-free.

Topiramate is a drug that decreases irregular brain activity but more research is needed to determine whether the benefits of this drug outweigh its side effects. Issues include confusion, inability to focus, dizziness, increased risk of having kidney stones, and osteoporosis.

Invasive Treatments

In cases where the non-invasive treatments listed above are not successful or tolerated by the patient, doctors can consider invasive treatments such as deep brain stimulation, occipital nerve stimulation, and sphenopalatine ganglion stimulation.

Nerve blocks can be injected at the back of the head on the same side which is affected by the pain. In rare situations, a nerve stimulator can be placed over the back of the head or neck to generate low-level stimulation in the affected area.

According to the study referenced above, research is also being conducted on Botulinum toxin-A, also commonly known as Botox, to investigate its effect on treating one and other headache disorders.

Can It Be Prevented?

As mentioned earlier, the exact cause of this condition is currently not known. Thus, there are no guidelines or methods to prevent this condition. However, research is currently being carried out to investigate the possibilities of preventing one.

According to the National Institute of Neurological Disorders and Stroke, amitriptyline and other tricyclic antidepressants have proved to be effective in certain people as a preventative treatment.

What’s The Difference Between Hemicrania Continua and Chronic Daily Headaches?

As mentioned earlier, a Hemicrania Continua can be easily confused with chronic daily headaches. It is important to differentiate the two in order for you to get the right treatment.

Chronic daily headaches are those head pains that occur on 15 days or more per month for a period of over 3 months. They can be short or long-lasting, such as those which last for more than 4 hours. Examples of long-lasting daily chronic head pains are migraines, tension-type headaches, and new daily persistent headaches.

Chronic daily head pains can affect “both sides of the head”. Tension-type headaches and new daily persistent headaches cause pain that feels like a pressing or tightening sensation while; hemicrania continua causes a throbbing sensation.

Chronic daily headaches do not cause nasal congestion and/or a runny nose which are typically symptoms associated with hemicrania continua.

Conclusion on What is a Hemicrania Continua

Hemicrania continua is a rare disease but it can interfere with your life in the long term and should not be taken lightly. If you are experiencing symptoms associated with this type of head pain, it is crucial that you go for a medical check-up to get a diagnosis.

During the doctor’s visit, make sure that you ask important questions such as the following:

  • Which medication do I need to take?
  • What are the side effects of this medication?
  • What is considered an emergency in this context?
  • Are there any particular symptoms that I need to be concerned about?

With the right treatment, you should be able to show a complete response to the medications and manage the symptoms effectively.

How to Cope with Daily Headaches

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Check This Headache Locations Chart to Pinpoint your Pain Before You See Your Doctor